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Genoa, a vibrant maritime city resplendent with art, churches and palaces, is Italy's sixth-largest city and the birthplace of Christopher Columbus. The newly renovated harbor has been transformed into a modern center of shops and eateries, and a walking tour through its historic streets is an opportunity to see the best of both the old and new architecture that decorates the city.

Upon arrival, begin a two-hour narrated pedestrian tour through a labyrinth of narrow cobblestone streets and alleys into Caruggi, the largest medieval center in Europe. This historical enclave, or Old City, includes some of the best-preserved medieval architecture in Italy, and your guide will explain the history of the area as you walk by and photograph the sights.

Situated between the old and modern centers of Genoa is Ferrari Square. Here you will find the spectacular restored fountain, a photo opportunity must, as well as several historical buildings, including the 19th-century Stock Exchange and the neoclassical opera house, one of the largest in Italy. In front of this majestic columned building, you will find a stately equestrian statue of Garibaldi.

Continue on to the ancient harbor front, redesigned and modernized by renowned Genoese architect Renzo Piano into an exuberant center of shops, eateries and attractions. Proceed to Caricamento Square for views of the 13th-century St. George Palace, then follow along Piazza Dante to the little house known as Casa di Colombo, where Columbus spent his childhood. The site was restored as part of the White House Millennium Project "Save America's Treasures.

One of the highlights of the tour is the 16th-century Ducal Palace, (Palazzo Ducale), once the residence of the Doges, later used to house the courts. From within its courtyard, your guide will point out the detailed façade of this fine building, the historic seat of the government of the Republic of Genoa in the 16th century.

Located nearby is the Church of Jesus (Loca Chiesa del Gesu), a former Jesuit church constructed in the 16th century. The baroque style of architecture used served as a model for Jesuit churches throughout the world. Inside there are two paintings by renowned artist Peter Paul Rubens.

As you approach the San Lorenzo Cathedral (Cattedrale di San Lorenzo), you'll be struck by its dramatic Romanesque Gothic façade. Constructed between the 12th and the 16th centuries, it has two majestic stone lions standing guard protecting the many religious relics housed inside, including the Sacro Catino, believed to be the Holy Grail.

At the completion of your guided walking tour, you will have free time to browse through the shops and boutiques along the Sottoripa, which has the atmosphere of an old-world bazaar. Pop into small markets and cafes, and chat with the locals over a cappuccino or pan dolce Genovese, the famous cake of the Ligurian region, studded with raisins and candied citrus peel. It is the perfect snack to savor on your relaxing drive back to port.